Liquid Glucosamine For Pets

Many liquid glucosamine chondroitin supplements currently available on the market are safe for animals. Many pet owners provide glucosamine for their dogs, horses, and other animals that are prone to arthritis and joint problems as they age. Just like people benefit from joint supplements, animals do too.

People vs. Pets

Glucosamine is just as safe for people as it is for pets. Animals will benefit from greater joint mobility and decreased pain in much the same way as people do. According to studies, large doses of glucosamine in animals had no adverse effects in animals, on glucose metabolism or on health generally. Side effects overall were very minimal.

Overall, glucosamine has proven a very safe and effective natural supplement for pets and people suffering from degenerative arthritis. In liquid form it is easy to administer, and tastes great too.

Topical Glucosamine

Topical Glucosamine for Pain Relief

Topical glucosamine is a valuable and effective therapy in pain management for individuals with osteoarthritis. There is much support for the relief of pain when compared with NSAID, though research is not as supportive of other topic pain relievers, including capsaicin though they are widely marketed.

Topical glucosamine is useful for local application of pain relief, as compared to transdermal glucosamine which delivers glucosamine locally but also provides systematic pain relief. Studies demonstrate that Tylenol has a weak effect on osteoarthritis pain and the potential for liver damaging consequences. Other side effects may include gastrointestinal effects and kidney adverse effects.

Topical Glucosamine: A Good Alternative

Contrastingly, topical glucosamine has few side effects and by and large is considered safe for patients with mild and moderate osteoarthritis particularly of the knee and hand. Research suggests topical glucosamine is a good alternative for individuals that are sensitive to the ingredients in most NSAIDs.

There are other topical agents available but there are no studies supporting their efficacy, and some including capsaicin may have serious side effects including desensitization of nerves or autonomic effects. Irritation to sensitive skin has also been observed with use of some alternative topical agents.

Glucosamine For Osteoarthritis Prevention

There is ample evidence supporting the use of glucosamine as a preventive agent in the war against osteoarthritis. According to some studies, individuals taking up to 1,200 mg of glucosamine sulfate and 1,500 mg of glucosamine hydrochloride report reductions in pain, swelling and stiffness associated with chronic arthritis.

Some researcher including studies published in the Archives of Internal Medicine show study participants taking glucosamine vs. a placebo show no progressive joint space narrowing or degeneration of cartilage over a period of three years vs. participants taking placebos who did demonstrate joint cartilage deterioration. This suggests that glucosamine is a preventive agent that helps protect joints from damage.

GAIT Study on Glucosamine

Many studies have promoted the efficacy of glucosamine include one large study known as the GAIT study. The results of this study proved overwhelmingly positive, indicating that glucosamine relieved pain; however the research team in this study claimed that the large placebo rate in the study may have obscured the results and thus the study may not have yielded accurate results.

Reviews of topical glucosamine show promising results, much like these studies; the only way to test the efficacy of topical glucosamine is by testing the product to determine how well it works for you.

References:
Altman, RD; Barthel HR; Topical therapies for osteoarthritis. Drugs. 2011. Jul 9; 71(10): 1259-79. PubMed. Available: http://www.ncbi.nlm.nih.gov/pubmed/21770475
Pavelka K; Gatterova J; Olejarova M; Machacek S. Giacovelli G; Rovati LC. Glucosamine sulfate use and delay of progression of knee osteoarthritis: a 3-year, randomized, placebo-controlled, double-blind study. Arch Intern Med. 2002 Oct 14; 162(18): 2113-23.

Organic Glucosamine

Organic Glucosamine for Sensitive Immune Systems

Of all the glucosamine supplements available organic glucosamine offers the best quality ingredients particularly for individuals with sensitive immune systems. Often arthritis results from auto-immune conditions. Organic glucosamine has no fillers, therefore it is perfect for people with auto-immune arthritis resulting from chemical sensitivities or reactive arthritis which may react to the fillers present in ordinary glucosamine which may include fillers in addition to glucosamine sulfate and glucosamine hydrochloride ingredients.

Organic Glucosamine Benefits

Organic glucosamine has been proven to provide benefits including pain and redness relief for knee osteoarthritis. While some researchers still debate the long-term effects of glucosamine, consumer reviews overwhelmingly support the use of glucosamine as a pain reliever.

Preliminary research also suggests that glucosamine may help benefit glaucoma and relieve other inflammatory conditions including psoriasis, provided it is taken in conjunction with other natural anti-inflammatory supplements. These include Omega-3 fatty fish oils.

Organic Glucosamine vs Traditional Medicines

Organic glucosamine is a natural supplement that works to improve the body’s own production of glucosamine, found in cartilage. Glucosamine sulfate is a substance that compromise the cartilage and synovial fluid which helps cushion the joints and bones. Glucosamine found in nature works as well if not better in some instances that traditional remedies which include administration of NSAIDs to relieve pain.

Unfortunately NSAIDs cannot reverse damage associated with joint deterioration. NSAIDs also cannot slow joint deterioration. However studies of organic glucosamine show that using glucosamine for as little as 3-months can yield positive results.
Benefits of Organic Glucosamine

Organic glucosamine yields many benefits whether used alone or in conjunction with fish oils, chondroitin, MSM, or even when used with a small dose of over-the-counter pain relieving medicines for severe flair ups. Consistent users can expect to need less medication over time as inflammation in the body is reduced.

Organic Glucosamine’s Overall Effect

As the body begins to heal, light exercise can be engaged to help further flush out inflammation in the body. This will also promote better sleep, which is essential for relieving pain and inflammation. To top it off, regular consumption of organic glucosamine will stimulate a desire to eat well, particularly as pain continues to drop off and a positive life outlook become ordinary existence.

References:
Sawitzke AD, Shi H; Finco MF; Dunlop DD; Harris CL; Singer NG; Bradley JD; Silver D; Jackson CG; Lane NE; Oddis V; Wolfe F; Lisse J; Furst DE; Bingham CO; Reda DJ; Moskowitz RW; Williams HJ; Clegg DO. Clinical efficacy and safety of glucosamine, chondroitin sulphate, their combination, celecoxib or placebo taken to treat osteoarthritis of the knee: 2-year results from GAIT. Ann
Rheum Dis, 2010. Aug; 69(8): 1459-64. Epub 2010. PubMed: Available: http://www.ncbi.nlm.nih.gov/pubmed/20525840

Glucosamine Uses

Multiple Glucosamine Uses

There are many glucosamine uses based on solid clinical research and evidence investigating the use of glucosamine against knee osteoarthritis. Many of the studies of glucosamine used glucosamine preparations including glucosamine HCL and sulphate to treat chronic arthritis sufferers. Patients with severe arthritis pain benefited in some instances with daily support using up to 1,200 mg of glucosamine sulfate and 1,500 mg of HCL glucosamine.

Glucosamine Supplemental Benefits

Some research supports glucosamine uses in categories not standardized for treatment. Typically people turn to glucosamine as a joint support supplement. However recent research suggests that glucosamine uses may include treatment of TMJ. Glucosamine may relieve chronic joint pain and stiffness if taken daily for a minimum of 90-days. This relief may be ongoing. Further, glucosamine may effect positive changes including a permanent reduction in stiffness among TMJ sufferers and may even prevent joint degeneration in at-risk patients.

Glucosamine and Glaucoma

Other studies support research suggesting glucosamine may act as a preventive agent or reduce the risk of glaucoma in some at-risk patients. More research is necessary in this area.

Glucosamine and Chronic Venous Insufficiency

  • There is evidence supporting the use of glucosamine to support chronic venous insufficiency, a condition contributing to leg swelling, varicose veins and other painful problems including skin and leg ulcers.
  • Glucosamine is commonly used in Europe to treat this condition, and even prescribed in Europe for this condition.
  • There is not enough clinical evidence to firmly support these claims, the preliminary research looks promising.

Glucosamine and Inflammation

  • Other research related to glucosamine uses suggest that the reduced inflammation caused by glucosamine may be helpful for relieving inflammatory bowel disease and related gastrointestinal processes.
  • Suggests glucosamine uses may include a reduction in ulcerative colitis and Crohn’s disease.
  • Glucosamine products most helpful with regard to this condition may include N-acetyl glucosamine.

Glucosamine and Tissue Repair

  • Leg pain may also be reduced by daily supplementation with glucosamine
  • Studies also support supplementation with glucosamine following a knee surgery or other physical therapy.
  • Research suggests that glucosamine uses include improved flexibility, lubrication, and faster healing times because of the likelihood that glucosamine may promote connective tissue repair.

Glucosamine Links to Rheumatoid Arthritis

There is even some research linking glucosamine to auto-immune condition rheumatoid arthritis. While most studies have focused on osteoarthritis, some research suggest that glucosamine may benefit rheumatic sufferers. More research is needed in this area; but because glucosamine demonstrates systemic anti-inflammatory action, there is hope that facts may be uncovered to support glucosamine uses in this area of health and wellness.

References:
Clegg DO; Reda DJ; Harris CL; et al. Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis. N Engl J Med. 2006 Feb 23: 354(8): 795-808.

Glucosamine Phosphate

What is Glucosamine Phosphate?

Glucosamine phosphate is part of an enzyme that helps facilitate a chemical reaction, the products of which help stimulate glucose metabolism and the process by which glucosamine is produced in the body. Glucosamine phosphate is essential for carbohydrate synthesis in the body, and a source of energy for a substance known as phophoenolpyruvate.

Glucosamine phosphate aids in sugar metabolism, assisting in conversion of carbohydrates and successful catalyzation of chemicals in the body during transport of carbohydrate sugars in various bio systems. Glucosamine phosphate is part of natural glucosamine in the body, part of the glutamate metabolic pathways, nucleotide metabolic pathways, and phosphotransferase systems or PTS enzymatic pathways in the body.

Aging and Body Deterioration

As with any metabolic system, with aging the body slows down. Metabolic systems deteriorate and begin to function less optimally. Chronic diseases, obesity, poor eating habits and poor health tend to affect the ability of the body to metabolize sugars and fats.

Glucosamine Supplementation

Supplementation with glucosamine may help correct metabolic imbalances and promote less inflammation in the body, which can affect glutamate metabolism, sugar metabolism and the PTS.

Glucosamine Phosphate Benefits

Glucosamine phosphate is helpful for reducing inflammation and improving the overall health and wellness of many body functions. Researchers have confirmed a link between the effects of glucosamine on connective tissue and cartilage, showing that glucosamine in many forms, including sulfate, hydrochloride, chitosan, and n-acetylglucosamine can help restore damaged tissues and improve synovial fluids. It stands to reason that supplementation with glucosamine may improve glucosamine phosphate enzymatic activity in the body as well. This may improve glutamate metabolism and carbohydrate metabolism.

Glucosamine Phosphate Side Effects

Research has shown relatively few side effects associated with consumption of glucosamine, although some studies suggest a link may exist between insulin resistance or glucose intolerance and glucosamine consumption. This link is weak however, and further studies are necessary to confirm whether a risk exists for patients with sugar metabolism problems.

Glucosamine has far fewer side effects than traditional treatment methods for inflammation, including less stomach problems and a reduced chance for hepatic toxicity.

Glucosamine is very beneficial, recommended by many researchers to improve glucosamine phosphate and improve carbohydrate metabolism thereby improving overall sugar and carbohydrate metabolic function, leading to decreased systemic inflammation throughout the body.

References:
Banda K; Gregg CJ; Chow R; Varki NM; Varki A. Metabolism of vertebrate amino sugars with N-glycolyl groups: mechanisms underlying gastrointestinal incorporation of the non-human sialic acid xeno-autoantigen N-glycolyneuraminic acid. J Biol Chem. 2012 Jun 12. Pub Med Available; http://www.ncbi.nlm.nih.gov/pubmed/22692204
Davidson, EA; Blumentha, HJ; Roseman S. Glucosamine 6-phosphate N-acetylase. Methods Enzymol. 9(1): 704-707. Available: http://www.sciencedirect.com/science/article/pii/0076687966091420

Glucosamine For Knee Pain

Glucosamine for Osteoarthritis

One of the healthiest and most readily available supplements for osteoarthritis is glucosamine for knee pain. Knee osteoarthritis is well-known as a disabling condition. Roughly one third of senior citizens suffer from knee pain resulting from degenerative forms of arthritis.

Typically osteoarthritis strikes individuals age 55+ but it can begin much earlier. Knee pain also results from overuse injuries and chronic auto-immune conditions which eat away at the connective tissues in the joint of the knee.

Glucosamine for Knee Pain Treatments

Many restorative agents are recommended to improve knee health. These include weight loss, exercise, physical therapy and corticosteroid injections. Injections of steroid agents come with many side effects. Another popular treatment protocol that comes with side effects that may be life-threatening despite the seeming benign application is NSAIDs. Ibuprofen, COX-2 inhibitors and other anti-inflammatory agents carry with them huge implications when used over the long-term to treat chronic pain.

Glucosamine as Alternative Treatment

Some osteoarthritis patients are prescribed very powerful pain medications, including narcotic pain medications to treat severe osteoarthritis. This can lead to addiction and dependence on pain medication. These types of pain medications can become overpowering, and not address the root causes of pain.

Natural Knee Pain Relief

There are many natural pain relievers on the market today, including glucosamine for knee pain. Other topical agents exist for knee pain including menthol and capsaicin cream. Capsaicin cream, while natural, may burn skin and cause irritation. Some studies report permanent nerve damage following application of this remedy.

Long-Term Effects of Glucosamine For Knee Pain

Glucosamine has been shown to have long-term effects on knee pain. It reduces swelling and inflammation, but may have other health benefits as well, including restoration of damaged connective tissues and cartilage. For this reason glucosamine is gaining a reputation as a disease modifying agent. Researchers are scrambling to gather more evidence to prove that glucosamine can heal pain but also begin repairing the connective tissues that are damaged in diseases including osteoarthritis. There is some preliminary evidence suggesting that glucosamine may reduce inflammation and restore tissues in other areas of the body as well, including in the eyes. Glaucoma is one area of research that scientists are focusing on; in all likelihood research will uncover many benefits glucosamine has yet to offer.

Glucosamine for knee pain has many benefits and few side effects, making it an ideal health food and supplement for taking away pain and inflammation, so knee pain sufferers can once again enjoy a happy, health, safe and active lifestyle.

References:
Ringdahl, E; Pandit S. Treatment of knee osteoarthritis. Am Fam Physician. PubMed. Available: http://www.ncbi.nlm.nih.gov/pubmed/21661710

Glucosamine and Weight Gain

Glucosamine: Effective Supplement

Glucosamine has widely been touted as an effective natural supplement for treating osteoarthritis, which it is; however little advertising has emphasized the link between glucosamine and weight gain, or rather the link between glucosamine and weight loss. Which is relevant?

Health, Glucosamine and Weight Gain

Many individuals have explored the link between glucosamine and weight gain, particularly as it has gained press regarding its benefits related to joint and cartilage health. Evidence in recent years has tied glucosamine and weight gain. This is linked to the potential for glucosamine to cause insulin resistance when administered in vitro or via injection. Some study participants seemed to develop metabolic syndrome and type-2 diabetes, but researchers are not clear whether the cause is glucosamine or some other underlying factor.

Insulin Resistance Causes Weight Gain

Glucosamine and weight gain may not be linked. There may be other causes for weight gain. Insulin resistance is a cause or symptom of type 2 diabetes. In this condition the body has to secrete more insulin to remove glucose from the blood into the body’s muscles and cells. An individual may have high blood sugar. There are many potential causes for insulin resistance including hereditary ones.

Glucosamine and Body Energy

Glucosamine helps to create energy in the body using an amino sugar. Glucosamine operates in the Hexosamine Pathway in the body, telling cells how much sugar they need to function optimally.

Some studies suggest that interfering with this pathway may lead to insulin resistance, or that glucosamine interferes with the natural biorhythms of this pathway, particularly when injected into the body.

Glucosamine and Weight Loss

However, there are also studies showing that glucosamine has no effects on this pathway and therefore is safe even for diabetics and individuals with glucose intolerance. There are not at present any long-term studies that measure the effects of taking glucosamine, and therefore many researchers argue it is impossible to link glucosamine and weight gain.

There are even conflicting studies with regard to the benefits of glucosamine on pain, stiffness and the potential for reversing cartilage and connective tissue damage in the body.

Glucosamine and Weight Gain Still a Mystery

Ultimately the best step is to consult with a healthcare professional and to weigh the pros and cons of any supplement before trying it. There are no definitive answers regarding glucosamine and weight gain, but there are some studies which also suggest that glucosamine may promote weight loss; thus the jury is still out on this subject.

References:
Anderson, JW; Nicolosi, RJ; Borzelleca, JF. Glucosamine effects in humans: a review of effects on glucose metabolism, side effects, safety considerations and efficacy. Food Chem Toxicol. Feb; 43(2): 187-201.

Dog Arthritis Glucosamine

Dog Arthritis

Arthritis affects everyone including dogs; fortunately there is help for everyone including dogs in the form of dog arthritis glucosamine. Arthritis is inflammation of the joints in the body of a human or dog which can lead to damage and changes in the joint and cartilage; the bones that are involved can degenerate or become stiff, and pain results.

Types of Dog Arthritis

There are many forms of arthritis dogs develop. Some of the more common forms of arthritis in dogs include osteoarthritis, auto-immune arthritis, reactive and arthritis with an undetermined cause, sometimes called idiopathic.

Signs and Symptoms of Osteoarthritis in Dogs

Dog arthritis glucosamine is most often recommended by vets to treat osteoarthritis and auto-immune arthritis. Signs and symptoms of osteoarthritis in dogs may include:

  • Lack of interest in walking.
  • Inability to climb stairs.
  • Pain in the joints.
  • Swelling in one or more joints.
  • Lameness or limping.

Many causes may influence dog arthritis including aging most naturally. Some dogs experience injury or illness that may contribute to the onset of arthritis. Sometimes eating too much or improper weight may contribute to arthritis in canines, or lack of exercise. Other causes include poor diet which can lead to bone deformity.

Diagnosing Dog Arthritis

A qualified healthcare professional must help diagnose arthritis, and the correct form of arthritis in dogs. Typically this can be accomplished using many different methods including x-rays, physical examination palpitation, and analysis of joint fluid, urinalysis, and overall physical.

Glucosamine Treatment for Dog Arthritis

The best treatment approaches for dog arthritis may depend on the dog. Many veterinarians will recommend dog arthritis glucosamine. Glucosamine for dogs is a naturally occurring supplement that may be offered in liquid or powder form to help with digestion.

Research has shown that glucosamine is highly effective for relieving joint pain, stiffness and the degenerative changes associated with arthritis.

Dog Arthritis Surgery

Sometimes surgery is necessary to stabilize a joint, particularly when injury occurred as a result of trauma. In instances like this, dog arthritis glucosamine may still be beneficial, particularly during recovery periods. A pet owner should consult with a veterinarian regarding proper dosing, and a fitness and exercise or stretching program that may help to stabilize and strengthen then the canine joint depending on the type of injury and the length of expected recovery.

Glucosamine Effectiveness for Dog Arthritis

Results of studies suggest that glucosamine detection in the blood of canine’s reaches maximum efficacy after just 90 to 180 minutes, thus it is a fast acting method of pain relief for animals and people, with dog arthritis glucosamine dosing expected to be effective at lower dosing and thus a lower cost than what many might expect, making it an affordable option for daily maintenance.

References:
Biggee BA; Blinn, CM; McAlindon TE; Nuite M; Silbert, JE; Low levels of human serum glucosamine after ingestion of glucosamine sulphate relative to capability for peripheral effectiveness. Ann Rheum Dis. 2006 February; 65(2): 222-226.

Cheapest Glucosamine

Glucosamine Forms

Glucosamine comes in many forms, and doesn’t have to be expensive to work; in fact, the cheapest glucosamine works to help relieve pain.

The many forms of glucosamine widely available on the market today include glucosamine sulfate hydrochloride, chitosamine, and N-acetyl-glucosamine. Which form is best? The two most naturally occurring and often cheapest glucosamine products available are glucosamine hydrochloride and liquid glucosamine sulfphate. These products are readily available from any retailer.

Why Glucosamine Is Important

Glucosamine is found naturally in the body, created from amino acids and glucose. Glucosamine is a necessary compound for repairing body tissues and cartilage, and providing fluid that helps cushion joints to move easily. Over time and with age the body does not produce as much of this compound, causing bones to become more fragile and to rub against each other.

This can lead to pain and discomfort. Fortunately researchers have discovered that cheap glucosamine can be an effective remedy for repairing joint cartilage that is worn down. Traditionally western medicine has employed the use of NSAIDs (Non-Steroidal Anti-Inflammatory Agents) to combat joint pain and stiffness when cartilage wears out. These medications are only effective for short periods of time, and do nothing to address connective tissue that degenerates.

Cheap glucosamine products however, not only address pain and discomfort, but may also help restore connective tissue and cartilage. Some researchers refer to glucosamine as a disease modifying agent, because early studies suggest there may be radiological evidence to market glucosamine as a restorative agent.

This means that glucosamine may actually help build new tissues and cartilage in the body. Cartilage is a basic building block of bone and joint material. In essence a person may actually build younger, healthier bones by taking advantage of cheap glucosamine, which some brands sell for as little as $12 to $15 a bottle.

Glucosamine Side Effects

Unlike NSAIDs, which have many long-term damaging side effects including bleeding, the potential for liver damage, and ulcers, glucosamine has few side effects including nausea. People allergic to shellfish however should stay away from some cheap glucosamine products, because many are derived from shellfish including crabs, lobster and other sea animals that are highly allergenic.

Not all forms of glucosamine are manufactured this way however, as some come from grains including corn that are modified chemically to produce glucosamine. Glucosamine may have other side effects, be sure to monitor your health and wellness while taking cheap glucosamine, and check with your healthcare provider regarding the safety and efficacy of any health supplement.

References:
Anderson, JW; Nicolosi, RJ, Borzelleca, JF. Glucosamine effects in humans: a review of effects on glucose metabolism, side effects, safety considerations and efficacy. Food Chem Toxicol. 2005 Feb; 43(2): 187-201.

Celadrin vs Glucosamine

Many consumers shopping for joint pain relievers will compare celadrin vs. glucosamine in an attempt to buy the best quality and most efficient joint pain relieving product. Which one is most likely to get the job done?

The Skinny On Celadrin

When comparing Celadrin vs. glucosamine it is important to understand the facts and similarities between Celadrin vs. glucosamine. There are currently many endorsements supporting Celadrin, and many clinical studies on Celadrin vs. glucosamine. It is difficult to tell how much is fact vs. how much is fiction regarding both supplements.

Celadrin is created using cetylated esterfield oils, which are similar to essential fatty fish oils. These oils work on the cell membranes of the joint and work to lubricate the joint so it becomes more flexible. Celadrin thus works as a flexibility agent, working much in the same way as synovial fluid may.

Glucosamine vs. Celadrin Studies

Glucosamine vs. Celadrin studies show that both may inhibit platelet aggregation. Other studies demonstrate that over the course of one month Celadrin was effective for reducing pain and improving functional performance especially in the knee among OA patients.
Other performance improvement indicators included reduction in severe pain in the elbow in OA and in rheumatoid patients, and improvement in pain in the write, even in patients only using the treatment for one week.

Range of motion and balance and strength improvements were reported in as little as one week, as were improvements in muscular strength and endurance. Celadrin like glucosamine has been shown to have few side effects, and is affordable when compared to other treatments for long-term pain including arthritis pain. Some researchers note that participants believe Celadrin is more effective than glucosamine, while others highlight its uses when used in conjunction with or when co-administered with glucosamine.

Glucosamine vs. Celadrin Comparison

Celadrin may be used daily or as an adjunct therapy for acute injuries resulting from over-exertion and inflammation resulting from over fatigue and resulting injuries. Celadrin vs. glucosamine comparisons seem to indicate that Celadrin is a good choice when compared to NSAIDs, and comparable if not better than glucosamine for treating joint pain including persistent arthritis.

References:
Kraemer, WJ; Ratamess NA; Maresh CM; Anderson JA; Volek JS; Tiberio, DP; Joyce ME; Messinger BN; French DN; Sharman MJ; Rubin, MR; Gomez, AL; Silvestre R; Hesslink RL Jr. A cetylated fatty acid topical cream with menthol reduces pain and improves functional performance in individuals with arthritis. J Strength Cond Res. 2005 May; 19(2): 475-80.
Lin PC; Jones SO; McGlasson DL. Effects of glucosamine and Celadrin on platelet function. Clin Lab Sci, 2010. Winter, 23(1): 32-6.